Marcelino Confidence growing at Valencia

first_imgValencia coach Marcelino Garcia Toral believes that his side are beginning to show flashes of their form of last season after defeating Manchester UnitedLos Che claimed a memorable 2-1 win over United at the Mestalla on Wednesday night in their final game of Group H in the Champions League.The victory may not have been enough for Valencia to qualify for the knockout stages of the competition, but Marcelino reckons the result has given his players a timely boost.“Whenever you win the mood is different, when players have the perception that they have had a good individual and collective performance you can see that in their looks,” said Marcelino on the club website.“The other day I saw details that remind me of Valencia CF from last season, scoring at the start of the first half or the second.“Undoubtedly, victories produce joy and increase confidence, they show that this team has not forgotten to do things well, it has always been competitive, and with a favourable result we dare to do more things.”Now Valencia’s focus will turn to this evening’s showdown at SD Eibar, where they hope to kick-start their La Liga campaign.FC Barcelona, Valencia CFMatch Preview: Barcelona vs Valencia Boro Tanchev – September 14, 2019 Is derby time in La Liga, as Barcelona welcomes Valencia to the Camp Nou Stadium tonight at 21:00 (CET).After finishing fourth last season, Valencia find themselves down in 15th-place with just three wins from 15 games.Although Marcelino knows all to well not to underestimate Eibar, who defeated Real Madrid 3-0 at their home ground last month.“It is clear that it is a very intense team, based its game on playing forward with precision, speed and decision,” said Marcelino.“it is the team that finishes the most in the area, generates many chances of goal and they play in a tough stadium.“We know what the idea and style of the opponent is, and this year we will try to counteract them and win, we have the illusion and the ambition to win.“They scored three goals against Real Madrid and four against Levante UD in their last two home games.”last_img read more

6 Singles From Black Panther The Album Hit Billboard Hot 100

first_img Black Panther Singles Climb Billboard Hot 100 6-singles-black-panther-album-hit-billboard-hot-100 Facebook News “King’s Dead” and “Pray For Me” are joined by six newcomers from Wakanda on the latest Billboard Hot 100, led by “All The Stars”Philip MerrillGRAMMYs Feb 21, 2018 – 1:52 pm As the movie Black Panther and Kendrick Lamar’s curated Black Panther: The Album continue to make inroads, more tracks have hit the Billboard Hot 100, while Black Panther: The Album hit No. 1 on the Billboard 200 for the week ending Feb. 15.In the most recent tally on Feb. 24, two songs were on the Hot 100 from the previous week — “Pray For Me,” combining Lamar with The Weeknd, at No. 11, while “King’s Dead” moved from No. 69 up to No. 38, blending Lamar with James Blake, Future and Jay Rock.Lamar and SZA’s “All The Stars” entered the Hot 100 at position No. 9. Its official video was posted on YouTube Feb. 6 and is now up to more than 27 million views. Other tracks making their first appearance include “X” at No. 49 by 2 Chainz, Saudi and Schoolboy Q. This is Saudi’s personal debut on the Hot 100.One of the love songs featured on our recent Valentine’s Day playlist, “The Ways” by Khalid and Swae Lee enters at No. 63. SOB X RBE, who just announced they’d be touring with Post Malone, debut on the chart at No. 67 with their powerful “Paramedic!”The two other Black Panther Hot 100 newcomer tracks are the catchy “Big Shot” at No. 71, with Lamar and Travis Scott, trailed by the lyrical powerhouse “Black Panther” rap of Lamar’s at No. 91.Stay tuned to see what other cultural products of Wakanda explore the Billboard charts on their own.Catching Up On Music News Powered By The Recording Academy Just Got Easier. Have A Google Home Device? “Talk To GRAMMYs”Read more Email Twitter 6 Singles From ‘Black Panther: The Album’ Hit Billboard Hot 100 last_img read more

The Wilmington Insider For June 13 2018

first_imgWILMINGTON, MA — Below is a round-up of what’s going on in Wilmington on Wednesday, June 13, 2018:Happening Today:Weather: Scattered showers, mainly after 1pm. Increasing clouds, with a high near 77. Southwest wind 6 to 8 mph. Chance of precipitation is 30%.Municipal Meetings: The Wilmington Board of Appeals meets at 7pm in Town Hall’s Room 9. Read the agenda HERE. … The Wilmington School Committee meets at 7pm in the High School’s Large Instruction Room. Read the agenda HERE.In The Community: The Wilmington-Tewksbury Chamber of Commerce’s is holding a Mega Multi-Chamber Networking event from 4:30pm to 7:30pm at the Tewksbury Country Club (1880 Main Street). Join a fun evening of networking at the beautiful Tewksbury Country Club. This popular Multi-Chamber event attracts 150-200 local professionals. Mark your calendar, gather your business cards & company brochures and make your reservation to attend today. $10 for members, $20 non-members. General networking will take place from 5:30pm to 7:30pm, with complimentary appetizers and a cash bar. An optional free seminar on Google Analytics with presenter Israel Kloss will be held from 4:30pm to 5:30pm.In The Community: WCTV is hosting a Podcast Meetup at 7pm at WCTV Headquarters (10 Waltham Street). Drop by for this informal introduction to Podcasting! Everyone welcome! If you’ve always wondered what Podcasting is all about or have Podcasts that you enjoy listening to–or if you’d like to create your own–come to WCTV and share your ideas, learn how to use our Podcast studio and meet like minded individuals. No fee to attend. Contact lkapala@wctv.org for more details!In The Community: The Wilmington Police Department offers safety seat installs at the Wilmington Public Safety Building (1 Adelaide Street) every Wednesday, from 10am to 2pm. No appointment is necessary, but calling ahead at 978-658-5071 is recommended. Learn more HERE.In The Community: The Friends of the Wilmington Memorial Library’s Book Store Next Door (183 Middlesex Avenue) is open from 10am to 4pm. All books are $2 or less!  Every penny of every sale benefits the Wilmington Memorial Library. Learn more HERE.At The Library: Tech Lecture: Product Safety at 7pm. [Learn more and register HERE.]At The Senior Center: SBF Exercise at 9:45am. Special Exercise at 11am. Country Line Dancing at 1pm. Cards at 1pm. Fun Singers at 3pm. [Learn more HERE.](NOTE: What did I miss? Let me know by commenting below, commenting on the Facebook page, or emailing wilmingtonapple@gmail.com. I may be able to update this post.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… Related5 Things To Do In Wilmington On Monday, July 22, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Monday, August 12, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Thursday, August 15, 2019In “5 Things To Do Today”last_img read more

Recent Wilmington Real Estate Transactions

first_imgWILMINGTON, MA — Below are real estate transactions in Wilmington during the week of September 9, 2018:Address: 9 Adams StreetPrice: $659,900Buyer: Michael A. Bergeron & Kathryn BergeronSeller: Michelle A. BallouDate: 9/11/18Use: 1-Family ResidenceLot Size: 22,216sfAddress: 7902 Pouliot PlacePrice: $415,000Buyer: Maggie Tabach-LopesSeller: Richard C. Trainito & Teresa E. TrainitoDate: 9/14/18Use: 1-Family ResidenceLot Size: 4,356sfAddress: 150 Salem StreetPrice: $369,000Buyer: Jeffrey Tucker & Tanya TuckerSeller: Anita Arsenault Est. & Elaine TuckerDate: 9/14/18Use: 1-Family ResidenceLot Size: 23,958sfAddress: 279 Shawsheen AvenuePrice: $390,000Buyer: John L. JacksonSeller: Paul J. Howell, Jr. & Gregory J. HowellDate: 9/11/18Use: 1-Family ResidenceLot Size: 18,731sfAddress: 52 Washington AvenuePrice: $543,000Buyer: Kurtis A. DubeSeller: Rafik M. Bishara & Julie N. RheaultDate: 9/14/18Use: 1-Family ResidenceLot Size: 47,045sfLike Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedRecent Wilmington Real Estate TransactionsIn “Business”Recent Wilmington Real Estate TransactionsIn “Business”Recent Wilmington Real Estate TransactionsIn “Business”last_img read more

Wilmington Youth Center To Hold Preview Night For 5th Graders On March 15

first_imgWILMINGTON, MA — Attention all 5th graders living in Wilmington!  Have you heard about the Wilmington Youth Center?  Are you curious as to what the 6th, 7th and 8th graders are doing?  Are you waiting anxiously until you become a member?The Youth Center Board invites you to a Preview Night on Friday, March 15, 2019, from 7pm to 9pm, to give you the opportunity to come by and check out the Center!  The Center is located in Villanova Hall (126 Middlesex Avenue), behind St. Thomas Church.The Youth Center offers a variety of activities, including:Board GamesJuke BoxFoosballPing PongBilliardsVideo Games for: PlayStation 3 / PlayStation II / WII / X-Box KinectVideo Arcade Room and Arcade-Style BasketballThrough the season, the Center sponsors craft nights, whiffle ball, and DJ dancesPizza, soda and candy are also available for purchase each weekThe Wilmington Youth Center has responsible adult supervision on duty from the time the Center opens until after the children have been picked-up. There is no registration fee for this “Preview Night.” Parents are asked to accompany their children in on this evening to leave a contact number with the Center. Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington Youth Center To Hold Preview Night For 5th Graders On March 4In “Community”5 Things To Do In Wilmington On Friday, March 15, 2019In “5 Things To Do Today”WILMINGTON GIVES: Wilmington Youth Center Seeks Video Game DonationsIn “Community”last_img read more

Houston Advocates Release Action Plan To Improve How Immigrants Survive Disasters

first_imgLiving Hope Wheelchair AssociationA member of the Living Hope Wheelchair Association visits immigrants recovering from Harvey.Advocates rolled out an action plan Friday to make disaster response in Houston more inclusive of immigrants.The Houston Immigration Legal Services Collaborative, and other community partners, released the action plan.  The plan included 34 recommendations, which were put together after studying the experiences of service providers at 40 immigrant-serving organizations. They found many immigrants faced additional barriers during and after Harvey.  X 00:00 /00:49 To embed this piece of audio in your site, please use this code: Sharecenter_img Listen Recommendations include providing better explanations on how to apply for FEMA assistance and making disaster preparedness information more accessible. “There’s not just the right languages and the right channels but even the right levels of literacy,” said Katy Atkiss, who developed the action plan. She also said some aspects of the action plan apply directly to the emergency response to the ITC tank fire. “Making sure that people know what to do, like what does ‘shelter in place’ mean,” she said. “If they even hear these words, how do they respond, what are their action items?”Atkiss will be meeting with local officials and organizations to see how the plan could be implemented.Elizabeth Trovall/Houston Public MediaKate Vickery of the Houston Immigration Legal Services Collaborative announces the Humanitarian Action Plan for immigrant resilience.In a written statement, County Commissioner Rodney Ellis said the industrial fires this week are a reminder to invest in the resilience of low-income and immigrant communities. “Immigrant resilience is key to the resilience of our country as a whole. For these reasons, I’m proud to support these recommendations,” said Ellis, who represents Precinct One.Episcopal Health Foundation/Kaiser Family FoundationA report by the Episcopal Health Foundation and the Kaiser Family Foundation found undocumented immigrants as more likely to say their lives were disrupted by Harvey than native-born residents.Other recommendations in the action plan include suspending immigration enforcement within 200 miles of disaster zones during a crisis, developing more data to better understand how immigrant communities are impacted by disaster and coordinating with immigrant advocates on getting out information to communities. last_img read more

DC Public Schools Fail to Meet Benchmarks

first_imgKaya Henderson, chancellor of D.C. Public Schools (DCPS), along with Mayor Muriel Bowser (D) and the D.C. Office of the State Superintendent of Education (OSSE) announced Nov. 30 that assessments from standardized testing showed District’s students largely failing to meet benchmarks for college preparedness.Close Up Of Student Lockers In High SchoolAccording to the data supplied by OSSE, only one out of every four District of Columbia students in grades 3 to 8 is are actually receiving the skills they need to be prepared for college or a career. “The PARCC scores show that D.C. Public Schools still have a lot of work to do to prepare every student for a successful future in college and a career. This year’s test serves as an important baseline from which we will work to help prepare all students,” Henderson said in a written statement.  “DCPS is committed to having difficult, but honest, conversations with families about how their children are doing.”The situation is much worse for many Black students in some of the city’s poorest neighborhoods, where the percentage of elementary and middle schoolers, who are “on track” for college and careers, often dip into the teens or single digits, the data shows. In fact, at some schools, no students met the new college and career readiness benchmarks set through the Partnership for Assessment of Readiness for College and Careers, or PARCC, a newly adopted testing system that replaces the old District of Columbia Comprehensive Assessment System (DC-CAS).“Some of our lowest performing schools continue to be low performing because they face tremendous challenges,” said Kaya Henderson, citing high concentrations of poverty as one of several obstacles that such schools must overcome. “It’s not okay if some of our schools are doing okay and some are not.”According to data from the office:Only 17 percent of Black students in grades 3-8 met the math expectation under the new assessment, versus 70 percent of White students.Similarly, only 17 percent of Black students in grades 3-8 met the English language arts expectation, versus 79 percent of White students.The percentage of “at-risk” students – that is, those on welfare, homeless or in foster care – as well as economically disadvantaged, and English Language Learner students who met the math and English standards were also low, ranging from 10 to 17 percent.With the District’s poor results, there is room for vast improvement. “These results set a new baseline and reflect the higher standards the District adopted to ensure students achieve 21st century college and career readiness,” said State Superintendent Hanseul Kang in a statement. “Just as scores improved on the DC CAS over time, the District expects scores to improve on the PARCC assessment.”But others are not so assured that scores can rise in the current system.  “What is most troubling about these results is that the test charts how students apply knowledge, not just what they know.  It means the District is not teaching our kids how to be critical thinkers,” said Charlotte Chambliss, a parent of a DCPS student enrolled at Jefferson Middle School, in Southwest. “These measurements suggest our kids are dim – because they are not ready for college or a job – and that is simply not the case.”Public charter schools outperformed DCPS in most areas, said Scott Pearson, executive director of the D.C. Public Charter School Board. “I point that out not to thump our chest, and I also do so with the full knowledge that public charter schools are not strictly comparable to public schools,” he said. “But it’s important to highlight this performance because it shows that charter schools are fulfilling their promise of delivering results for DC’s families.”According to the data, 21 percent of Black public charter school students in grades 3-8 met the English language arts standard, versus 13 percent of Black students in the same grades in DCPS. It also shows 22 percent of Black public charter school students in grades 3-8 met the math standard, versus 12 percent of Black students in the same grades in DCPS.The higher performance of public charter schools was particularly beneficial for Black students, who met the new college and career readiness standards at nearly twice the rate of Black students in DCPS. “One of the things that we’re really proud about with our charter schools is that when we look at our very best charters, they’re not just concentrated in more affluent areas,” Pearson said. “Many of what we call our Tier One charter schools are in Ward 7, in Ward 8, in high poverty areas around the city.”last_img read more

Fire at Moonda Kotee tea estate none hurt

first_imgDarjeeling: A fire broke out at Moonda Kotee tea estate in the wee hours of Saturday. The office of the tea garden was totally gutted thereby destroying all documents, records and the computers of the garden. There has been no report of any injury or loss of life.The garden is situated around 4 km below Sonada in the Kurseong sub division of the Darjeeling district. The fire broke out around 12:30am on Saturday. “Tea garden workers and local residents tried to douse the fire. We even tried to contact the fire brigade but failed to do so. Soon, the office was razed to the ground,” stated Puran Rai, assistant manager of the tea estate. Incidentally, there had been a fire in the factory of the garden in 2004, in which the factory was gutted. The garden is owned by Darjeeling Organic Tea Estate Pvt Ltd. They have a worker strength of 949. 298. Seventy-eight hectares of land is under tea cultivation in the garden.last_img read more

Tap Into Online Safety

first_imgSeptember 1, 2007 Opinions expressed by Entrepreneur contributors are their own. Entrepreneur: Online fraud seems to be a popular topic, but has the percentage of fraudulent transactions on eBay actually increased?Rob Chesnut: There is less fraud on eBay today than there was three years ago. In the past five years, we’ve built our own fraud engine and now have a global team of 2,000 safety experts dedicated to identifying potential fraudulent activity. We’ve stayed ahead of a fast and challenging environment, and we’ve really made an impact. But I’m not satisfied. Fraud at any level on eBay just isn’t acceptable.Entrepreneur: Can you describe the most common forms of fraud?Chesnut: Fraud usually occurs when buyers take transactions offline, away from the safe confines of eBay. In the rare instances it occurs on eBay, it’s seller fraud committed on buyers, such as when the buyer sends payment and the seller fails to ship the merchandise, it gets lost or what the buyer receives isn’t what was advertised. In those cases, the buyer files a complaint against the seller. The higher-dollar transactions have more potential for [fraudulent activity].For sellers, the key issue is how to handle problem customers. Are you willing to live with [potential] negative feedback? Will you accept returns? Is the customer always right? The greater the level of trust you build, the more successful you’ll be. Trust is determined by the number of transactions you’ve completed, the number of positive feedbacks you’ve received and whether or not you accept returns.Entrepreneur: What is the difference between trust and safety?Chesnut: Safety from potential crime and fraud is a prerequisite for trust. The more you do to demonstrate that you are a trustworthy seller, the safer your buyers will feel and the more they will buy from you.Entrepreneur: What new features has eBay instituted to combat fraudulent transactions?Chesnut: We just launched a number of initiatives designed to eliminate fraud and ensure safer transactions. Our Safeguarding Member IDs project helps prevent off-site fraud by hiding the bidder’s User ID on transactions over $200 so buyers don’t receive spam. We’ve also put restrictions on items popular with fraudsters and on luxury brands to keep counterfeits off the site. And we are much less tolerant of sellers who offer buyers a mediocre customer experience. New feedback features enable buyers to give more detailed ratings, so sellers can differentiate themselves and buyers can make more informed decisions.Entrepreneur: What can sellers do to protect themselves against fraud?Chesnut: First, be suspicious of anyone who wants to complete a transaction offline. Second, communicate with buyers, and read their feedback history to see what they’ve bought and sold before. Third, offer a safe and secure payment method such as PayPal, which offers you and your buyers a high level of protection. Fourth, never click on suspicious links or phishing e-mails, and be sure your computer has the latest browser–Internet Explorer 7 or Firefox, which have built-in phishing protection. Finally, use common sense and be wary of unusual listings.Marcia Layton turner writers regularly on small-business issues and is author of The Unofficial Guide to Marketing Your Small Business. 3 min read Growing a business sometimes requires thinking outside the box. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Register Now »last_img read more

Malicious code in npm eventstream package targets a bitcoin wallet and causes

first_imgLast week Ayrton Sparling, a Computer Science major at CSUF, California disclosed that the popular npm package, event-stream, contains a malicious package named flatmap-stream. He disclosed the issue via the GitHub issue on the EventStream’s repository. The event-stream npm package was originally created and maintained by Dominic Tarr. However, this popular package has not been updated for a long time now. According to Thomas Hunter’s post on Medium, “Ownership of event-stream, was transferred by the original author to a malicious user, right9ctrl.  The malicious user was able to gain the trust of the original author by making a series of meaningful contributions to the package.” The malicious owner then added a malicious library named flatmap-stream to the events-stream package as a dependency. This led to a download and invocation of the event-stream package (using the malicious 3.3.6 version) by every user. The malicious library download added up to nearly 8 million downloads since it was included in September 2018. The malicious package represents a highly targeted attack and affects an open source app called bitpay/copay. Copay is a secure bitcoin wallet platform for both desktop and mobile devices. “We know the malicious package specifically targets that application because the obfuscated code reads the description field from a project’s package.json file, then uses that description to decode an AES256 encrypted payload”, said Thomas in his post. Post this breakout, many users from Twitter and GitHub have positively supported Dominic. In a statement on the event-stream issue, Dominic stated, “I’ve shared publish rights with other people before. Of course, If I had realized they had a malicious intent I wouldn’t have, but at the time it looked like someone who was actually trying to help me”. As a support to Dominic, André Staltz, an open source hacker, tweeted, Users affected by this malicious code are advised to eliminate this package from their application by reverting back to version 3.3.4 of event-stream. If the user application deals with Bitcoin, they should inspect its activity in the last 3 months to see if any mined or transferred bitcoins did not make it into their wallet. However, if the application does not deal with bitcoin but is especially sensitive, an inspection of its activity in the last 3 months for any suspicious activity is recommended. This is to analyze the notably data sent on the network to unintended destinations. To know more about this in detail, visit Eventstream’s repository. Read Next A new data breach on Facebook due to malicious browser extensions allowed almost 81,000 users’ private data up for sale, reports BBC News Wireshark for analyzing issues and malicious emails in POP, IMAP, and SMTP [Tutorial] Machine learning based Email-sec-360°surpasses 60 antivirus engines in detecting malicious emailslast_img read more

Cardinals claim waived Browns OT Desmond Harrison

first_img The Arizona Cardinals successfully put in a claim on offensive tackle Desmond Harrison a day after he was waived by the Cleveland Browns.Because Arizona is first in the waiver claim order, that means the team was able to add the second-year offensive lineman.Arizona released offensive lineman Andrew Lauderdale from the roster in order to make way for Harrison.Harrison was let go after he missed a flight and the first day of Cleveland’s mandatory mini-camp Tuesday, Browns head coach Freddie Kitchens told reporters. A source told Cleveland.com’s Mary Kay Cabot it was “one too many missteps” for Harrison, an undrafted player who started eight games as a rookie left tackle last season. Former Cardinals kicker Phil Dawson retires Comments   Share   Harrison won the starting left tackle job and started in every game before head coach Hue Jackson and offensive coordinator Todd Haley were fired by the Browns in 2018. He was replaced at tackle by Greg Robinson and never won back the starting role.Related LinksCardinals CB Robert Alford: ‘Time for me to step up’ with loss of PetersonCardinals hope to help Larry Fitzgerald as much as he helps themCardinals’ David Johnson ‘honors’ Carson Palmer with self-made hatVance Joseph: Cardinals defense ‘compliant’; Murphy coming alongThe 6-foot-6, 305-pound tackle entered the NFL Draft Combine two summers ago after he put up the second-fastest 40-yard dash time for a lineman at 4.90 seconds.Harrison went undrafted out of West Georgia in 2017 and began his career at Contra Costa Community College. He earned First Team All-American honors there before he joined Texas for his junior season. Harrison was ruled academically ineligible initially but was eventually cleared.He was suspended multiple times at Texas before leaving the program and spent two years away from football prior to joining West Georgia.The Cardinals can at least get a strong look at Harrison as mandatory mini-camp begins on Tuesday.Three of Arizona’s tackles in D.J. Humphries, Marcus Gilbert and Korey Cunningham are all coming off season-ending injuries. Bud Dupree #48 of the Pittsburgh Steelers is held in the end zone by Desmond Harrison #69 of the Cleveland Browns resulting in a safety during the third quarter in the game at Heinz Field on October 28, 2018 in Pittsburgh, Pennsylvania. (Photo by Justin K. Aller/Getty Images) Derrick Hall satisfied with D-backs’ buying and selling Top Stories The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Grace expects Greinke trade to have emotional impactlast_img read more

She joined Hannah Cockroft on her lap of honour af

first_imgShe joined Hannah Cockroft on her lap of honour after finishing seventh behind Britain’s double gold medallist in the T34 200 metres in London 2012.But four years on, Mel Nicholls believes she has a real chance of causing an upset and beating Cockroft in one of her three events in next month’s Rio Paralympic Games.In London, the T34 track races were sprints – 100 and 200 metres – but in Rio there will be a T34 100 metres, a 400 metres and an 800 metres, a race which gives the mid-distance specialist Nicholls a much better chance of a medal.She told Disability News Service: “I have definitely got a chance.”A silver medal in the 800 metres at last year’s world championships was a “great boost”, she said, coming as it did soon after an injury lay-off.She’s world record-holder at 1,500 metres and loves the tactics of the longer races.Nicholls (pictured) said: “I am much more of a distance racer, I am not a sprinter. It definitely goes in my favour.“[The 800 metres] is still a short middle distance but you have got a good lap of time for some tactics, which I absolutely love. That’s my thing.“I see it as like a game of chess. Once you’re into the rhythm you can kind of see it… I know where people are, I know what I can do, and you just play it out, and that makes it really exciting.“With the 800, it’s almost anybody’s race. There are about five of us who can medal. I definitely want to be in that top five.”London 2012 was her first major competition as a wheelchair athlete, and she took part just four years after the last of three strokes which left her disabled.The build-up to Rio has been completely different to London, when she was “a complete unknown”.She said: “I wasn’t on the radar [at London]. I am now. I put a lot of pressure on myself, but since London I’ve been on the team and it’s my job, so there is a lot of different pressure.“That’s really exciting, but it’s a very different feeling.”Nicholls describes herself as a “perfectionist”, both as a person and as an athlete.She said: “There’s no harder taskmaster than I am on myself. You want to be the best you can be.“Also, I don’t want to let my team down. I’m really part of the team. My coaches, the country, everybody that’s invested in me and the sport, I feel I owe them back.“Always I want to please people; I want to please my coaches, my friends, my family. I work myself the hardest because I don’t want to let anybody down.”She copes with the stress and pressure partly through support from a sports psychologist and mindfulness training, which she said has “probably been my biggest help in my training”.The mindfulness proved crucial at last year’s world championships, she said, when she had only returned to training a month before, after an injury, and was lacking in confidence.She said: “I got a silver medal and it was my mind that got me through that race. Your mind is powerful and you can do a lot with that.”Like many Paralympians, she has had to make sacrifices. She hasn’t seen her mother, who lives in France, since last year.Nicholls said: “I don’t see my friends very much; sometimes they can get quite frustrated about that. I don’t see my family.“They understand that. It’s a short time and a small price to pay, I think. I know that they are there backing me and afterwards it will be worth it.”She is looking forward to the “vibrance and the colour” of Rio – “I am a fan of bright colour, everyone knows me for always being in pink” – and to being part of a team environment again.She said: “That was the main thing I noticed from London. I had never been in a team environment before and it felt like a big family.“The people supporting you back home and the team around us, it was a big family, and everyone was there for the highs and the lows.”She said that putting on the Rio 2016 ParalympicsGB team kit for the first time was “wonderful”.She said: “Putting on the kit is something really special. I can imagine putting on a wedding dress, it’s that kind of experience… I will take this over getting married any day.”She added: “We have this amazing crown design, which I absolutely love. It’s very regal. I love the royal family, I absolutely love the Queen, so I think it’s fantastic. If I could wear a crown to race, I would.”Like many Paralympians, she is hoping to inspire the next generation of athletes, as she was inspired herself by watching the 2008 Beijing Paralympics.She remembers joining Cockroft on her 200 metres lap of honour in London.She said: “It was the children, their faces, and they all wanted to high-five you. You could see the magic in their eyes, and that was really special, and that was disabled children or able-bodied children.“For me, if one person is going to take up sport, that’s such a positive, that’s what I want to do.”Nicholls put her wish to inspire the next generation of Paralympic athletes into action five years ago by starting an academy with her coach, basing it at the Coventry Godiva Harriers athletics club.There is now a core group of at least 10 athletes at every session, three times a week, and another 40 people who drop in and out; some of those who attend the sessions are amateurs and some of them professional athletes.She said: “Some of the children do it because it’s a social thing, they have friends there, but they are getting better and better.“The older guys want to come and get fit because they haven’t had the opportunity before.“So we have Paralympic athletes training with everyone else; everyone just mixes in.“It’s a social thing, it’s a confidence thing, a health thing and a competitive thing as well.”One of those training with her at the academy is 15-year-old Kare Adenegan, who watched Nicholls and Cockroft race four years ago in London and made headlines last September after becoming the first athlete to beat Cockroft in her senior career.Adenegan will be racing alongside and against both Nicholls and Cockroft in Rio.last_img read more

How to Solve Twitters Biggest Problems

first_img Add to Queue Twitter January 18, 2017 Columnist at PCMag.com Twitter’s problems stem from being a modern tech company that isn’t growing fast enough. I have two solutions. Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Image credit: Shutterstock Fireside Chat | July 25: Three Surprising Ways to Build Your Brand This story originally appeared on PCMagcenter_img 3 min read Enroll Now for $5 –shares There has been a lot of discussion about Twitter lately, most of it negative — it can’t make money on advertising, growth is down and online bullies remain a problem.Meanwhile, Donald Trump tweets daily; more every day since the election. This alone, you’d think, would draw more attention to Twitter and make it more popular. Twitter actually does over $2.5 billion in revenue, but tech companies are supposed to grow like crazy, not freeze up at a mere $2.5 billion dollars, which is ludicrous.   With that revenue, all Twitter needs to do is have a bunch of sales folks sell the ads and a slew of IT guys keep the thing running. That should not cost billions, although it looks like it does.So what’s the solution to this “problem”?When I listen to all the pundits, I see two solutions. The first is never brought up for any other billion-dollar company: stabilization. In other words, do nothing.In tech, there is a never-ending mad dash for growth. It stems from the late 1990s, when one company would replace another after the simplest of stumbles. The financiers, mostly venture capitalists, demanded high performance growth so they could dump the company and do it all over again with some other crazy idea. This is an unnatural way to do business. Most businesses stabilize and become fixtures. Not so with tech, where everything seems like a fad.Online customers can easily drop one thing and flock to another. Thus, Twitter’s $2.5 billion in revenue could drop to a billion — or nothing — almost overnight. It cannot just stabilize and coast for as long as possible, or die a natural death, or morph the way AOL morphed. It is a spawn of the go-go tech grow-like-crazy-or-die syndrome.The irony is that such companies often get acquired by other growth-oriented places like Google or Facebook. What happens then? They slowly die a natural death … usually quicker.Twitter, unlike many of these operations, has a different dimension, though. It’s a kind of public service. It breaks news and can trigger revolutions or protests. It’s casual, too. Twitter is an enjoyable product if you are not attacked by its mad dogs.That’s not to say there aren’t problems with Twitter. There is some sort of corruption with the “Who to follow” recommendations; it seldom makes sense especially for those signing up for a new account. Maybe that’s part of its advertising, although I do not think so. There is a lot of spam. I find fake accounts daily and do not see how they can possibly remain unless Twitter wants phony numbers. That said, its core users seem content.Which brings us to the second solution, which is simple. Do what LinkedIn did and add a premium tier. I’d pay $5 or $10 a year for an upper tier account. There are over 300 million active users. Sell them something! How hard can it be? John C. Dvorak How to Solve Twitter’s Biggest Problems Next Article last_img read more

Governors Veto Stalls Vermont Legislation to Legalize Marijuana

first_img Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Add to Queue –shares Free Green Entrepreneur App Next Article Governor’s Veto Stalls Vermont Legislation to Legalize Marijuana dispensaries.com Voters are far more willing to legalize cannabis than the representatives they elect. Vermont’s movement to become the first state to consider legalizing recreational marijuana without a vote of the people got derailed this week when Gov. Phil Scott vetoed the measure.Scott rejected a bill that allowed for possession of small amounts of marijuana. The measure also created a commission to study how to set up a regulated adult-use marijuana market in the state, with recommendations on how it might work delivered by November.It did not create a regulated adult-use marijuana market, such as voter-passed measures did in eight states, including Colorado, Washington and California (a distinction lost in many media reports). Scott, a Republican, rejected it, anyway. However, he also made it clear he’s not opposed to legalization and left the door open to compromise.The only roadblock to completing a deal will likely be members of his own party.Related: Congressional Cannabis Caucus Unites to Protect Marijuana IndustryNot philosophically opposed.The other eight states to legalize recreational marijuana all did so through a popular vote by the people. Vermont lawmakers wanted to make possession legal through legislation, and also set up a commission that could eventually recommend how the state could create, regulate and tax an adult-use marijuana market.Other states have watched closely how things turn out in Vermont. Some lawmakers in Illinois, for example, are considering introducing similar legislation. Their issue mirrors that in other states – they want the tax money marijuana brings in to help balance the state budget.For Scott, marijuana legalization presents a bit of a legal quagmire. A Republican serving his first year in office, Scott has politicians in his party vehemently opposed to legalized, adult-use marijuana.However, the bill, passed in the Legislature by a narrow margin, had approval of 57 percent of the state’s voters, according to this survey from March.Scott told reporters after his veto of the bill that he is “not philosophically opposed to eliminating the prohibition on marijuana,” he just wants some changes.Related: San Diego Company Bids to Become First Marijuana Business on NYSEFew changes needed.Actually, the changes Scott wants are relatively minor, leading Vermont newspaper the Burlington Free Press to report there might be a deal by summer.Most of Scott’s issues are about kids and time. He wants:Longer sentences for those who use marijuana in front of children or offer it to children, as well as more severe penalties for driving under the influence of marijuanaMore time for the state to study the regulatory structure needed to have a legal marijuana market, perhaps pushing it back to 2019 or beyondThe Vermont Legislature goes back into session in late June and there could be a compromise worked out there. State Sen. Dick Sears, a Democrat, told the Free-Press its “not a slam dunk but it’s possible.”But while Scott has proposed a compromise, his own party may keep it from happening. Rep. Don Turner, a Republican, said the majority of Republicans lawmakers remain opposed to legalization and will not likely change their minds.Follow dispensaries.com on Twitter to stay up to date on the latest cannabis news. Image credit: Martin Bernetti | Getty Images May 30, 2017 Download Our Free Android App 3 min read Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine. Guest Writer Cannabis Opinions expressed by Entrepreneur contributors are their own.last_img read more

How to Work On a Flight With No Laptop

first_img This story originally appeared on PCMag How to Work On a Flight With No Laptop The laptopocalypse is coming. In one of the most insane tech and travel related decisions I’ve ever seen, the Department of Homeland Security is considering banning any electronic device larger than a smartphone on a wide range of commercial flights.I won’t get into the purported security rationale for this, except to say that we wouldn’t be “completely safe” in the air even if we all flew naked; terrorists could just put bombs where the sun don’t shine. In terms of 2017, flying without laptops and tablets makes business travelers feel pretty naked. In fact, airlines have downgraded their in-flight entertainment offerings over the past few years assuming that travelers are bringing their own gadgets.The mechanics of any future ban will probably play out like the ban on large electronic devices on flights from the Middle East, just on a much larger scale. Middle Eastern airlines have rallied by providing laptops and tablets to business and first-class customers. That doesn’t help coach class passengers on a 10-hour flight, though.Being forced to check expensive electronics would create all sorts of security and liability concerns. Right now, most airlines disclaim liability for damaged electronics in luggage. That means they won’t pay you if the baggage handlers break or steal your laptop.Airlines affected by the current Middle East laptop ban, for example Qatar and Etihad, have changed that policy. Hopefully, other affected airlines would as well. But even then, airlines may not pay you the full value of your damaged electronics: according to the Montreal Convention treaty, airlines are only responsible for about $1,560 worth of luggage per passenger on international flights.Pick the best airlineWith no laptop in the air, in-flight entertainment systems become more critical than ever. Every hour you spend watching that seatback screen is an hour you aren’t stressing about your laptop.So, first of all, don’t accept any flight without seatback screens. For transatlantic flights, various reports have said that Air Canada, Icelandair, Lufthansa and Virgin Atlantic are all good choices. Of the major U.S. based airlines, Delta gets the nod for best in-flight entertainment from Skytrax.Your mobile office: phone, keyboard, touchpad If your airline doesn’t lend you a laptop, it’s time to get used to working on your smartphone.Android and iOS phones support Bluetooth keyboards, and the Microsoft Office apps on these devices aren’t half bad. For email, web browsing and document management, you can get quite a lot done on your phone. Use a cloud storage service such as Dropbox or OneDrive for your documents, so you can access them on your home computer, your phone and any computers you get access to at the other end of your journey.You can get more done with a keyboard. The Logitech K480 Bluetooth keyboard works with your phone and includes a groove that will prop up your phone at the right angle on a tray table. There are a lot of smaller, weirder Bluetooth keyboards out there, but we really like this one.Not having room on your tray table for a mouse can be a problem, though. I tend to use a keyboard and the phone’s touch controls. Android users could also upgrade to the Logitech K830 keyboard, which has an integrated touchpad. iPhones don’t support Bluetooth mice or touchpads, alas.Stunningly, I think we’ve also just found a real use for Dex, the new desktop dock for Samsung’s Galaxy S8 phones. Bring a Dex dock with your S8, and you’ll be able to turn it into a desktop computer on the other end of your flight.For the kids: iPod touch Since the DHS ban applies to anything larger than a smartphone, that puts the tablets we use to entertain kids into peril. Even the Amazon Fire Kids Edition won’t hold up to this ban.Enter the iPod touch. Now available for $199, this will be family frequent fliers’ best friend: a small, portable entertainment device for kids that doesn’t require phone service and isn’t larger than a phone. Download movies from Netflix or the iTunes Store before leaving on a trip.There is no high-quality Android equivalent to the iPod touch. There were in the past, but they’ve gone off the market. If you don’t want an Apple product, your best bet is to get an inexpensive unlocked Android phone such as the $139 Moto G4 Play, and just not install a SIM card.How About Reading a Book?Books are good. Try one. Just not on an e-reader. They’ll be banned, too. The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue Image credit: Shutterstock Flights 2019 Entrepreneur 360 List Next Article center_img June 12, 2017 4 min read Sascha Segan Banning laptops on flights in 2017 is an insane idea, but here’s how to deal if it happens. 90shares Lead Mobile Analyst Apply Now »last_img read more

The Intranet Grows Up

first_imgTechnology Sarah Pierce From MySpace-style profiles to video blogs, check out the cool new things businesses are doing with their intranets. It wasn’t too long ago that intranets–internal company websites–were considered the redheaded stepchild of a business’s technology efforts. Once reserved for HR policies and company documents, intranets took a back seat to the company’s website as an underdeveloped–and rarely used–tool for employees.But many are turning their attention back to their intranet and discovering cool new ways to engage employees. Whether it’s MySpace-style profiles or video sharing, intranets have expanded from a corporate bulletin board to a social networking tool.Intranets in ActionInteractive promotion company ePrize, based in Pleasant Ridge, Michigan, expanded its intranet nearly 18 months ago to include more employee-centric features, including an area called the “Water Cooler” where employees can sell personal items, such as extra concert tickets and homes, and post announcements, such as needing a sub for the company’s softball team. Employees can also log into the system each morning to order from a daily lunch menu. The $4 lunches are automatically deducted from their paycheck and delivered that afternoon.Another new feature ePrize employees enjoy is the ability to create personal profile pages that include contact info, languages spoken, birthdays and wedding anniversaries.”The intranet is the way we stay connected and network within our company,” says Alesya Opelt, senior marketing director. “It isn’t a place reserved for boring HR guidelines and document sharing. We use our intranet as a place to interact, build and document our culture, and to get to know each other beyond just an e-mail address.”Developing intranets that allow employees to interact using the same tools they’re used to outside the workplace is a new trend many businesses are exploring successfully. Lois Paul & Partners, a public relations company headquartered in Woburn, Massachusetts, recently expanded its intranet from the usual company announcements, info and links to resources, by creating an “LP&P Underground” blog. The blog serves as an outlet for employees to talk about topics that interest them outside of work, such as the latest in pop culture, TV shows, music and other random topics.”It’s a nice way to take a break from the busy day to talk about something fun,” says Kristin Cronin, senior account representative. “It’s also a good way to get to know fellow employees a little bit better.”Cronin adds that the blog has been a great way for newer employees to engage with employees that have been with the company longer, and despite business owners’ fears, it hasn’t cut into productivity. “People here work hard and know when they have a few minutes to browse the latest blog posts and when they don’t,” she says. “Blog entries can be a quick thing that the multi-tasking Gen Yers, and even the Gen Xers, can handle with little interruption to work.”The AppealThis attempt to reach twentysomething employees is the crux of the new “social” intranet movement. As more and more Generation Y employees enter the workplace, employers have to find new and different ways to get employees involved.”What’s happening is people are gathering in intranet chat rooms to have events people used to have in a conference room,” says Richard Laermer, author of Punk Marketing and CEO of RLM PR, which helped its client Comcast be recognized as one of 2007’s “10 Best Intranets” by the Nielson Norman Group. “It’s a fun way to participate without having to go to a sock hop or company picnic, which is hard for people these days, who work more than they ever did,” Laermer adds.He encourages business owners to let employees share industry-related stories and video on the intranet. He refers to this as “edutainment”–the ability to blend educational material about the company and its field.”The last thing employees want to see on the company intranet is the company handbook,” he says. “Have a good time with it–put up videos and hold online chat sessions instead of meetings. Employers who set up intranets need to remember, it’s not supposed to be a brochure; it’s supposed to be ‘intra’-active.”Dr. Gerry McCartney, CIO of Purdue University, agrees. While other CIOs are trying to discourage viewing video online, he decided that if that’s how people want to communicate, then that’s the medium he should use. His video blog, Vignettes, engages his staff more than any e-mail or newsletter ever could, he says.McCartney sees the increasing use of Web 2.0 technologies as the future of the intranet. He predicts that as we move toward communicating more on mobile devices, businesses will begin delivering communication to employees via text messaging and providing access to the intranet through employees’ cell phones.Whatever stage your intranet is in, it’s time to pull it out of the past and start treating it as the valuable tool it is. Whether you’re connecting employees to important information or connecting them to each other, the intranet has become a powerful new way to internally strengthen your business. The Intranet Grows Up The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue –shares Apply Now » 5 min read 2019 Entrepreneur 360 List June 20, 2007 Next Article last_img read more

The Search Party Reinvented

first_img Learn how to successfully navigate family business dynamics and build businesses that excel. Most business owners are aware of the rudimentary keywords and tools necessary to promote their goods and services to consumers, but only search engine optimization experts fully grasp the myriad complexities that earn the maximum bang for your digital marketing buck. Now, thanks to Trada, any business can hire an army of SEO specialists–and even name its price in the bargain.Founded in late 2008 by Niel Robertson in Boulder, Colo., Trada is a crowdsourced paid-search marketplace that lets small businesses leverage the collective acumen of more than 700 certified search experts who earn their living generating low-cost clicks and conversions. Prospective advertisers come to Trada with basic information about who they are and what they do, establishing campaign parameters such as daily budgets, prices per click and target costs per conversion. From there, Trada taps its freelance expert network, and interested parties begin creating ad groups, keywords and ads. If the search experts sell the ad below the advertiser’s preset price, they keep the difference and give Trada 25 percent of their cut. “Paid search is such a big marketplace that it’s hard to get value out of it,” Robertson says. “The basic idea behind Trada was to create a marketplace system where advertisers spend what they want.” The Search Party, Reinvented Next Article • The typical small-business advertiser spent 159 percent more on search advertising this year than in 2009. Add to Queue Marketing Trada aims to make broader online marketing capabilities more accessible–and affordable–to any size business • Attorneys, general contractors and dentists were the most popular advertiser categories.–J.A. Magazine Contributor Small businesses are spending more on online advertising this year than in 2009–and seeing better returns on their investments. A recent report from WebVisible, an online marketing firm in Irvine, Calif., breaks it down: • Approximately 43 percent of all clicks resulted in a web conversion in the second quarter of 2010–an improvement of nearly 40 percent year-over-year.center_img • Conversion activity more than doubled from 2009 for form fills, video views, printed driving directions and bookmarking. This story appears in the November 2010 issue of . Subscribe » Twenty search experts collaborate on the average Trada campaign, which runs about 6,500 keywords and 110 ads across three search engines (Google, Yahoo! and Microsoft Bing). By comparison, the typical DIY small-business campaign incorporates about 60 kMost business owners are aware of the rudimentary keywords and tools necessary to promote their goods and services to consumers, but only search engine optimization experts fully grasp the myriad complexities that earn the maximum bang for your digital marketing buck. Now, thanks to Trada, any business can hire an army of SEO specialists–and even name its price in the bargain.Founded in late 2008 by Niel Robertson in Boulder, Colo., Trada is a crowdsourced paid-search marketplace that lets small businesses leverage the collective acumen of more than 700 certified search experts who earn their living generating low-cost clicks and conversions. Prospective advertisers come to Trada with basic information about who they are and what they do, establishing campaign parameters such as daily budgets, prices per click and target costs per conversion. From there, Trada taps its freelance expert network, and interested parties begin creating ad groups, keywords and ads. If the search experts sell the ad below the advertiser’s preset price, they keep the difference and give Trada25 percent of their cut.”Paid search is such a big marketplace that it’s hard to get value out of it,” Robertson says. “The basic idea behind Trada was to create a marketplace system where advertisers spend what they want.”Twenty search experts collaborate on the average Trada campaign, which runs about 6,500 keywords and 110 ads across three search engines (Google, Yahoo! and Microsoft Bing). By comparison, the typical DIY small-business campaign incorporates about 60 keywords and spans just one search engine.”We offer scale, delivered by people who know what they’re doing–they know how much to bid on keywords and how to write an ad,” Robertson says. “These are things that are not easy to learn. You should be an expert on your business, not paid search.”Google itself has taken notice of Trada: In July, Google Ventures invested $5.75 million in the startup in tandem with Foundry Group, a VC firm in Boulder, Colo. Trada has about 200 advertiser clients across multiple verticals who spend $3,000 to $50,000 per month.Robertson envisions the Trada concept expanding across all segments of online advertising. “It’s a pay-per-performance system, we don’t charge anyone a fee, and we only make money if we surpass the goals our advertisers set for us,” he says. “We’re all in this together.” Free Webinar | July 31: Secrets to Running a Successful Family Business 4 min read October 4, 2010 Upping the Ad Ante Jason Ankeny –shares Register Now »last_img read more

CTF along with NTAP and Sage announce firstever open data portal for

All content in the NF Data Portal is compatible with global scientific initiatives to establish common vocabularies and protocols for sharing data across all diseases. Furthermore, the NF Data Portal hosts analysis tools to integrate different modalities of data including drug efficacy across model systems, drug-target analysis, clinical trial data, and molecular adaptive responses in patients. The datasets coming from funded research are subject to a short embargo period (generally up to 18 months), during which the researchers will use the Data Portal for their own research before releasing the dataset to the research community under a Creative Commons (CC) license, or similar. The user-centered design approach employed by Sage Bionetworks for the NF Data Portal enables more users to easily find and access the data they need.As the portal evolves and grows, it will include data from other significant research programs, such as the CDMRP-NF program (Congressionally Directed Medial Research Programs in Neurofibromatosis), as well as other funders of NF research. All are welcome to participate.”We are very excited to have attracted the most important funders of NF research in order to enhance and expand use of the NF Data Portal, and to be working with Sage Bionetworks, which possesses the expertise to build what we consider to be the most promising model of data-sharing in the rare disease area,” said Salvatore La Rosa, PhD, Chief Scientific Officer of the Children’s Tumor Foundation.Sara Gosline, PhD, Senior Scientist at Sage Bionetworks and lead of the NF Open Science Initiative, added, “Through our work with CTF and NTAP we have been able to capture an unprecedented amount of data across the NF community that will undoubtedly fuel further scientific discoveries in this field.”La Rosa concluded, “This is big news for researchers, but ultimately even bigger news for patients, who can be assured that critical information is being shared openly so that treatments can be developed as quickly as possible.”Source: https://www.ctf.org/news/open-science-and-data-initiative-announced-for-neurofibromatosis Reviewed by James Ives, M.Psych. (Editor)Dec 17 2018The Children’s Tumor Foundation (CTF), together with the Neurofibromatosis Therapeutic Acceleration Program (NTAP) and Sage Bionetworks (Sage), has announced the first-ever open data portal for scientific research results in the field of neurofibromatosis (NF). The NF Data Portal marks the major first milestone in all three organizations’ commitment to the development of the larger NF Open Science Initiative (NF-OSI), which draws experts from across research disciplines and disease areas in order to develop treatments for NF, a genetic disorder which affects 2.5 million people worldwide (1 in 3,000 births), and currently has no cure or effective treatment options.The unique challenge for researchers studying NF, and particularly for patients living with the disease, is that NF is extremely variable. It causes tumors to grow on nerves throughout the body, and can cause deafness, blindness, disfigurement, bone abnormalities, learning disabilities, disabling pain and cancer. This makes diagnosis and treatment particularly difficult, and as a result, many patients are told to ‘watch and wait’ as their tumors grow. Researchers working on the disease have likewise faced the challenge of working in independent groups and relying primarily on data made public through published works.The Children’s Tumor Foundation looked to turn this ‘traditional research model’ on its head, and in 2014 launched the NF Open Science Initiative, in collaboration with Sage Bionetworks, in order to enable CTF sponsored project teams to share their data in real-time through Sage Bionetworks’ Synapse platform. This was started in connection with the Foundation’s Synodos research model, which brings together multidisciplinary experts from leading institutions and across basic, translational and clinical disciplines, in order to solve complex NF issues.This spirit of collaboration has attracted other significant partners, and in 2015, CTF committed to supporting data collection and integration from a large National Cancer Institute (NCI) project, called DHART SPORE (Developmental and HyperActive Ras Tumor Specialized Programs of Research Excellence). That same year, NTAP initiated a relationship with Sage requiring that data generated through NTAP funded initiatives be uploaded, harmonized and indexed within Synapse. Across all of these projects – from CTF to NTAP to the NCI – Sage Bionetworks interacts directly with the project scientists to coordinate data upload and organization, and applies expertise in computational biology, oncology, data harmonization, and community-building to expand and enhance the value of the data generated across all of these initiatives.Building on the success of these efforts, CTF, NTAP and Sage have formally aligned to launch the NF Data Portal and the NF Open Science Initiative to support:Related StoriesResearchers identify gene mutations linked to leukemia in children with Down’s syndromeHealthy lifestyle lowers dementia risk despite genetic predispositionBacteria in the birth canal linked to lower risk of ovarian cancer computational biologists seeking to analyze NF data and run their analyses, bench scientists who are interested in seeing what models/studies have been carried out on NF-related models, clinicians interested in seeing if a compound of interest has been used in an in-vivo, in-vitro or an in-silico model, and the general public who are interested in reading about what symptoms of NF are currently being studied. read more

Synthetic alcohol substitute could make hangovers a thing of the past

first_imgThere will obviously be testing to check the molecule is safe. And we need to show that it’s different from alcohol. We will demonstrate that it doesn’t produce toxicity like alcohol does and doesn’t have the bad effects of alcohol.” We know where in the brain alcohol has its ‘good’ effects and ‘bad’ effects, and what particular receptors mediate that. The effects of alcohol are complicated but… you can target the parts of the brain you want to target.” Commenting on the place Alcarelle may take in the alcohol industry, global drinks analyst, Jonny Forsyth, says the future is promising, given that the industry is increasingly investing in alcohol alternatives:”If the science is right, and if it’s easy to mask the taste, I think it’s got a great chance”. By Sally Robertson, B.Sc.Mar 27 2019Reviewed by Kate Anderton, B.Sc. (Editor)Professor David Nutt, an expert in neuropsychopharmacology, is aiming to make hangovers a thing of the past by introducing a synthetic alcohol alternative that provides the relaxing effects of alcohol, without causing hangovers and health problems. Jag_cz | ShutterstockNutt, who oversees the neuropsychopharmacology unit at the Imperial College London, believes that the alcohol substitute, which he has named “Alcarelle,” could change alcohol consumption, if it becomes regulated and available on the market.Nutt first discovered an antidote to alcohol in 1983 when studying the effects that alcohol has on the Gaba system. He realised that the antidote was too dangerous, but continued researching how Gaba receptors respond under the influence of alcohol.Nutt has now learned that 15 subtypes of Gaba receptor are present in multiple regions of the brain and that alcohol will bind to all of them. However, Alcarelle, he claims, can stimulate the Gaba receptors that cause tipsiness, without stimulating the receptors that induce negative effects such as headaches:center_img Furthermore, the way in which Alcarelle binds to a receptor can be modified to produce different effects, meaning a person could choose to feel the effects of drinking, whilst avoiding inebriation.Nutt and colleagues have been working on the Alcarelle molecule, also referred to as “alcosynth,” for more than a decade, but the final hurdle they face is bringing the product to the masses.“The real challenge is taking that molecule to a drink. The regulatory side is much harder than the science,” explains Nutt, who is currently working with his partner David Orren to raise the £20 million it would cost to bring Alcarelle to the market.However, the researchers have adopted a five-year plan in collaboration with food scientists to have the molecule regulated as a food additive or ingredient. Source:This story is based on an interview with David Nutt, published in The Guardian on the 26 March 2019: “Could ‘alcosynth’ provide all the joy of booze – without the dangers?”last_img read more

Combating hunger with artificial intelligence

first_img Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Matheus Thomas Kuska et al. Spectral Patterns Reveal Early Resistance Reactions of Barley Against Blumeria graminis f. sp. hordei, Phytopathology (2017). DOI: 10.1094/PHYTO-04-17-0128-R Mirwaes Wahabzada et al. Plant Phenotyping using Probabilistic Topic Models: Uncovering the Hyperspectral Language of Plants, Scientific Reports (2016). DOI: 10.1038/srep22482 AI is acquiring a sense of smell that can detect illnesses in human breath Citation: Combating hunger with artificial intelligence (2018, June 22) retrieved 18 July 2019 from https://phys.org/news/2018-06-combating-hunger-artificial-intelligence.html Journal information: Scientific Reports Almost 800 million people worldwide suffer from malnutrition. In the future there could be around 9.7 billion people—around 2.2 billion more than today. Global demand for food will increase as climate change leaves more and more soil infertile. How should future generations feed themselves?Kristian Kersting, Professor of Machine Learning at the Technische Universität Darmstadt, and his team see a potential solution in the application of artificial intelligence (AI). Machine learning, a special method of AI, could be the basis for so-called precision farming, which could be used to achieve higher yields on areas of equal or smaller size. The project is funded by the Federal Ministry of Food and Agriculture. Partners are the Institute of Crop Science and Resource Conservation (INRES) at the University of Bonn and the Aachen-based company Lemnatec.”First of all, we want to understand what physiological processes in plants look like when they suffer from stress,” said Kersting. “Stress occurs, for example, when plants do not absorb enough water or are infected with pathogens. Machine learning can help us to analyse these processes more precisely.” This knowledge could be used to cultivate more resistant plants and to combat diseases more efficiently.The researchers installed a hyperspectral camera that records a broadwave spectrum and provides deep insights into the plants. The more data available on the physiological processes of a plant during its growth cycle, the better a software is able to identify recurring patterns that are responsible for stress. However, too much data can be a problem, as the calculations become too complex. The researchers therefore need algorithms that use only part of the data for learning without sacrificing accuracy.Kersting’s team found a clever solution: To evaluate the data, the team used a highly advanced learning process from language processing, which is used, for example, at Google News. There, an AI selects the relevant articles for the reader from tens of thousands of new articles every day and sorts them by topic. This is done using probability models in which all words of a text are assigned to a specific topic. Kersting’s trick was to treat the hyperspectral images of the camera like words: The software assigns certain image patterns to a topic such as the stress state of the plant.The researchers are currently working on teaching the software to optimise itself using deep learning and to find the patterns that represent stress more quickly. “A healthy spot can for instance be identified from the chlorophyll content in the growth process of the plant,” said Kersting. “When a drying process occurs, the measured spectrum changes significantly.” The advantage of machine learning is that it can recognise such signs earlier than a human expert, as the software learns to pay attention to more subtleties.It is hoped that someday, cameras can be installed along rows of plants on an assembly line in the greenhouse, allowing the software to point out abnormalities at any time. Through a constant exchange with plant experts, the system should also learn to identify even unknown pathogens. “Ultimately, our goal is a meaningful partnership between human and artificial intelligence, in order to address the growing problem of world nutrition,” says Kersting. In order to improve world food conditions, a team around computer science professor Kristian Kersting was inspired by the technology behind Google News. Provided by Technische Universitat Darmstadtlast_img read more