May 17, 2006 (CIDRAP News) – The intranasal influenza vaccine FluMist proved to be 55% more effective than an injectable vaccine in a phase 3 trial of children aged 6 months to about 5 years, according to a press release from MedImmune, maker of FluMist.The study, involving 8,475 children at 249 sites in 16 countries, was presented May 1 at the annual meeting of the Pediatric Academic Societies in San Francisco.Lead author Robert B. Belshe, MD, director of the Center for Vaccine Development at St Louis University, said in the press release, “We discovered that [FluMist] was significantly more effective in protecting children against influenza infection. This is especially important, because this age-group is among the most vulnerable to influenza infection, and they tend to spread influenza to other family members.”In the news release, MedImmune cited plans to submit its data to the US Food and Drug Administration (FDA) by the end of June to seek an expansion of FluMist’s indications to include children from 6 months to 5 years of age. It is currently approved for healthy children and adults between 5 and 49 years.In the double-blind study conducted during the 2004-05 flu season, patients received either trivalent injectable inactivated influenza vaccine (TIV) or cold-adapted influenza vaccine, trivalent (CAIV-T). CAIV-T is a refrigerated form of FluMist, designed to be easier to handle than the current version, which must be stored frozen. The study included 6,300 previously unvaccinated children, half of whom were younger than 2 years.For the strains of influenza that the vaccines were designed for, FluMist was 44% more effective than the injected vaccine (flu attack rates: TIV, 2.4%; CAIV-T, 1.4%). However, FluMist was discovered to be even more effective compared with the injectable vaccine against a variant of the target H3N2 strain that appeared during the flu season studied (attack rates: TIV, 4.5%; CAIV-T, 1.0%), according to MedImmune.Thus, FluMist had a combined 55% greater rate of effectiveness against both matched and mismatched strains (overall attack rates: TIV, 8.6%; CAIV-T, 3.9%).William Schaffner, MD, chair of the Department of Preventive Medicine at Vanderbilt University, who was not involved in the study, underscored in a May 1 Associated Press (AP) story the importance of this broader protection. Schaffner said, “That’s very, very exciting, because we all know the influenza virus has a tendency to drift,” or mutate.The AP report said that FluMist might work better because it uses live, attenuated virus, as opposed to the dead virus in TIV. Belshe explained in the story that, while injectable vaccine is effective in healthy people who have caught flu before or been inoculated many times, immune-naïve babies and preschoolers need the more flulike nasal challenge provided by FluMist.MedImmune reported that overall adverse events and serious adverse events were similar in both groups of children, but the FluMist recipients had a 2.5% to 5.6% increase in runny nose and nasal congestion. Also, unvaccinated children experienced a small but statistically significant increase in medically significant wheezing—3.3%, compared with 2.0% in the TIV group.This increase in wheezing, though, was found only in the 42 days after the first dose, and not beyond 42 days or after the second dose, according to the news release. However, Schaffner, in a USA Today story, said the side effect “will be looked at very critically” by the FDA and by those who make vaccine policy.See also:May 1 MedImmune press releaseMay 1 St Louis University press releasehttp://www.slu.edu/readstory/more/6872
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Girls’ team: Sammy Fuller (Roehampton, Surrey), Lily May Humphreys (Stoke-by-Nayland, Essex), Hollie Muse (West Lancashire), Emily Price (Cleobury Mortimer, Worcestershire), Hannah Screen, (Berkhamsted, Hertfordshire), Bel Wardle (Prestbury, Cheshire). Amelia Williamson (Royal Cromer, Norfolk) was unwell and had to withdraw. Team captain Janet Melville said: “The plan this week was to try to win every session. We knew that wouldn’t be easy but we’ve managed it so we’re very pleased. We got off to a really good start this afternoon and they were all up early on so that took the pressure off a bit.” Tags: Girls’ Home International Clodagh Hopkins, the Ireland women’s captain, said: “This is just amazing. I can’t believe it has happened. The English are a very strong team but I had an inkling we could get something out of the match. The girls have played so well and been so positive all week that I knew they had a chance. Every time we went out we did just enough and that’s exactly what we did today.” Image courtesy The R&A This is England’s ninth win in 10 years and during the decade the team has been beaten only by Ireland in 2016. 11 Aug 2017 England’s girls reclaim their crown “The plan this week was to try to win every session. We knew that wouldn’t be easy but we’ve managed it so we’re very pleased. We got off to a really good start this afternoon and they were all up early on so that took the pressure off a bit. However, the England women’s team – who had won the last three championships – lost their title to Ireland, suffering a narrow 4-5 beating. Women’s team: Emma Allen (Meon Valley, Hampshire), Lianna Bailey (Kirby Muxloe, Leicestershire), Gemma Clews (Delamere Forest, Cheshire), India Clyburn (Woodhall Spa, Lincolnshire), Sophie Lamb (Clitheroe, Lancashire), Rochelle Morris (Woodsome Hall, Yorkshire), Olivia Winning (Rotherham, Yorkshire). Click here for full scores England captain Elaine Ratcliffe commented: “The Irish played some great golf on that back nine. It was still close after nine, we were up in two games, but the others were really close. You’ve got to hand it to the Irish.” England today reclaimed their crown as Girls’ Home Internationals champions, beating Ireland 6.5-2.5 to clinch the title on the final day at Little Aston, Staffordshire. The strong English team were in dominant form throughout the match despite losing Amelia Williamson to gastroenteritis on the eve of the championship. The English claimed the morning foursomes 2½-½ and then went further ahead in the singles when Hollie Muse and Sammy Fuller both won their sixth matches out of six by recording 6&5 victories over Lauren Walsh and Sara Byrne. The England team looked set to claim the title for the sixth time in seven years after sharing the morning foursomes and then taking an early lead in the singles, but that was before the Irish mounted a late comeback which resulted in them claiming their victory. Although the team was down to six players for the three-day tournament, England defeated Wales 8-1 and Scotland 7-2 before battling hard to defeat a tough young Irish squad on the last afternoon. read more